Developing biocatalysts for industrial chiral chemicals
Kyrobio will increase the capability of the European manufacturing industry to produce high value single enantiomer chiral molecules by the adoption of new biocatalytic processes. The targeted reactions are generation of C-C and C-N bonds in molecules with multiple chiral centres by the application of lyase enzymes.
Coordinated by C-Tech Innovation, Kyrobio will develop the synthetic potential of these enzymes which are currently underrepresented in the repertoire of commercially available biocatalysts. Kyrobio uses a supradisciplinary approach ranging from, enzyme development, chemistry, molecular biology, fermentation and innovative product isolation techniques in order to make better enzymes for industrial use.
What problem does it address?
Chiral molecules are important constituents of products, drugs, agrochemicals and speciality chemicals. Conventional synthetic methods are often inefficient in material usage, require use of organic solvents and toxic metals, and are energy intensive. Biocatalytic processes can revolutionise these processes as they typically use renewable resources for catalyst manufacture, reduce organic solvent usage, and are operated relatively mild conditions. The ‘toolkit’ of enzymes and relevant process technologies for chemical manufacturers is limited. Kyrobio will develop additional enzymes to increase the range of bio catalysed synthetic reactions which can be commercially exploited.
Who will benefit from the project?
The adoption of environmentally beneficial technologies will keep the European chemical industry at the forefront of white biotechnology by developing new processes and products to underpin future economic and employment opportunities.
Co-funded by the European Union under the Framework 7 Programme.